How Can PDE-Inhibitors Help to Fight Erectile Dysfunction?
ED is a very common pathological condition. Millions of men around the world suffer from it. This is due to many reasons, including the deterioration of the ecological situation on the planet, the growth of urbanization, as well as the increase in the average age of inhabitants of the Earth. It is important to note that ED is an inevitable consequence of aging. It can appear at any age as a pathology that can and should be treated.
An erectile dysfunction leads to the development of anxiety, self-doubt and even depression, significantly reducing the quality of life, both men and their partners. That's why it is necessary to deal with this problem as quickly as possible. Today any man suffering from this unpleasant problem can find the most suitable drug for the treatment after reading the cheap rx review and choosing the option according to your personal needs.
Which Role Do Inhibitors of Phosphodiesterase 5 (PDE5) Play in the ED Treatment?
Relaxation of the smooth muscles of the vessels of the cavernous bodies during erection depends on ensuring the release of calcium ions from the smooth muscle cells. This process is predominantly regulated by nitric oxide, which activates the enzyme guanylate cyclase (HZ). The enzyme GC, in turn, increases the synthesis of the secondary mediator - cyclic guanosine monophosphate (cGMP), and it promotes the leakage of calcium ions from the cavernous smooth muscle cells.
All this leads to a relaxation of smooth muscles, increases the flow of blood into the cavernous bodies and, thus, helps to achieve and maintain an erection of the penis. Phosphodiesterase type 5 inhibitors as a treatment of ED: PDE5 destroys cGMP, resulting in a reduction in the smooth muscle of the penis. Consequently, the inhibition of this enzyme increases the content of cGMP and as a result facilitates the occurrence of an erection.
Best ED Drugs that Can Help to Forget about ED
Revolutionary event in the field of the treatment of erectile dysfunction was the appearance in 1996 of the drug sildenafil citrate, which became known under the trade name "Viagra". This drug, taken internally in the form of tablets, increases the effectiveness of treatment.
The next approved PDE-5 inhibitor after sildenafil was tadalafil (Cialis). Unlike sildenafil, this drug has a long half-life (17.5 h) and its pharmacokinetics is not dependent on food and alcohol intake. Thus, the duration of the action of Cialis (36 hours) makes it possible to have several sexual intercourses and preserve the spontaneity and romanticism of sexual relations. You can get acquinted with the more detailed review of PDE-5 inhibitors here.